Central mucoepidermoid carcinoma cmc is an uncommon tumor, comprising 23 % of all mucoepidermoid carcinomas reported. Mucoepidermoid carcinoma of palatal minor salivary glands with intracranial extension. We report a case of mucoepidermoid carcinoma mec in the palate of a 43yearold female that exhibited a prominent oncocytic component. We report a case of an adult male who presented with a mucoepidermoid carcinoma involving the minor salivary glands of the palate at age 57 years, followed by an adenoid cystic carcinoma of the floor of mouth at age 63 years. Mucoepidermoid carcinoma involving the palate with.
Primary clear cell carcinoma of minor salivary gland of. Mucoepidermoid carcinoma of the hard palate sciencedirect. Mucoepidermoid carcinomas mec of minor salivary gland origin are rare in children and adolescents. Mucoepidermoid carcinoma mec is the epithelial salivary gland neoplasm of the oral cavity. Mucoepidermoid carcinoma soft palate rads iowa head. Management of mucoepidermoid carcinoma of the palate. Mucoepidermoid carcinoma of the soft palate salivary gland.
Global journal of otolaryngology issn 24747556 the palate. Mucoepidermoid carcinoma of minor salivary gland in buccal. Minor salivary gland carcinoma involving the oral cavity or oropharynx. Mucoepidermoid tumour, salivary gland neoplasms, minor salivary gland introduction.
Mucoepidermoid carcinoma palate low grade help cancer. Although the palate is reported to be the most common site, and recent reports have confirmed that mucoepidermoid carcinoma is the most common malignant neoplasm, we know of few large series of cases that outline the management of these cases. We report a rare case of highgrade mucoepidermoid carcinoma of maxillary sinus in a 45yearold female. Salivary gland tumors usually occur as single lesions. Mucoepidermoid carcinoma soft palate malignant epithelial salivary gland neoplasm 10% of all salivary tumors, 30% of all salivary malignancies about 30% of these tumors arise from the minor salivary glands in the buccal mucosa and soft palate, the rest from major salivary glands arises from ductal epithelium, has both epidermoid and mucinous components appearance. Minor salivary gland tumors in children are uncommon. The palate is the most frequent localization for those arising in minor glands. Mucoepidermoid carcinoma is the histologic subtype of salivary gland tumors for which grading is the most prognostically and therapeutically relevant factor seethala, 2011. Mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth. If you have problems viewing pdf files, download the latest version of adobe reader. Our case is of mucoepidermoid carcinoma of the anterior maxillary region and is in a rare site of occurrence since salivary glands are absent in this site.
We aimed to investigate clinicopathological features, therapies, and prognoses of eight mec cases. Mucoepidermoid carcinoma arising from mucous glands of maxillary sinus are extremely rare and accounts for % of all malignancies occurring in maxillary sinus. Salivary gland cancer treatment options include surgery with or without postoperative radiation therapy, radiation therapy, and chemotherapy. Joseph dental college and hospital, eluru, andhra pradesh, india. Central mucoepidermoid carcinoma of mandible a case. Primary central mucoepidermoid carcinoma of jaws is a rare lesion comprising 23% of all mucoepidermoid carcinomas reported in literature. I had very clear margins, however, as a precaution i will also be undergoing radiation in a couple of weeks. Mucoepidermoid carcinoma mec is the most common malignant salivary gland tumor and it is the 2nd most common among all salivary gland tumors pleomorphic adenoma being the most common.
Internet search disclosed cases reported from several countries. A rare case report article pdf available in journal of indian society of periodontology 202 january 2015 with 203 reads how we measure reads. An indurated lesion was noted on the left hard palate of the patient. The deep and diffuse distribution of salivary glands in the soft tissue of the head and neck region is one common limitation to the early diagnosis of pleomorphic adenoma pa from those glands. Mucoepidermoid carcinoma mec of the lung is a rare malignant neoplasm. Oncocytes in mucoepidermoid carcinoma of the palate. Of these, 143 cases qualified for inclusion in this study. The case presented here illustrates the hypothesis that its specific pathogenesis is unknown. Mucoepidermoid carcinoma mec is the most common primary salivary gland malignancy in both adults and children. Eight patients underwent surgical treatment for pulmonary mec between 2005 and 2012 at the thoracic surgical department of west china hospital, sichuan, china. Mucoepidermoid carcinoma abstract the mucoepidermoid carcinoma of the palate is an uncommon disease. Mucoepidermoid carcinoma, abbreviated mec, the is the most common malignant neoplasm of the salivary gland. Mucoepidermoid carcinoma of intraoral salivary glands.
Mucoepidermoid carcinoma of palate a rare entity ncbi. Because welldocumented cases of mucoepidermoid carcinomas that are of minor salivary gland origin and occur in children and adolescents have rarely been reported, little information regarding their clinical features and biologic behavior is available. Prognostic factors of palatal mucoepidermoid carcinoma. Mucoepidermoid carcinoma of the jaw is a rare tumour of unknown aetiology. Mucoepidermoid carcinoma of hard palate request pdf. However it can present in the minor salivary glands, especially in the soft palate. Hccc is a new and rare lowgrade salivary gland neoplasm which occurs in the primary clear cell carcinoma of minor salivary gland of the soft palate. My first biopsy said it was low grade, but post surgery they told me it was intermediate grade.
Most commonly affected major salivary gland is parotid gland, and the most common intraoral site is the posterior palate. Minor salivary gland mucoepidermoid carcinoma in children and. Mucoepidermoid carcinoma mec of the palate is a common malignancy of minor salivary glands. Jacobsohn3 bharat guthikonda1 1department of neurosurgery, lsuhsc shreveport, shreveport. The case presented is a 41 year old woman with central mucoepidermoid carcinoma. Salivary gland cancer is diagnosed in 23 individuals per 100,000 people each year, and 3035% of these are mucoepidermoid carcinomas. Abstract malignant tumors of the paranasal sinus are uncommon, constituting less than 1% of all malignancies and 3% of all head and neck cancers. Pet image shows a prominent nodular enhancing lesion over the palate outline arrow and mildly enhancing lymph nodes. A case report k a saleh, mrcs entglasg, nurishmah md.
Ive been diagnosed with mucoepidermoid carcinoma involving the minor salivary glands on the palate. Clinicopathological analysis of pulmonary mucoepidermoid. The purpose of this case report is to discuss the clinical manifestation, diagnosis, and treatment plan of mec of the palate. The two most common tumors were pleomorphic adenoma 181 cases, 33. Mucoepidermoid carcinomas mecs of minor salivary gland origin are rare in children and adolescents and have been reported rarely. We report the case of a 72yearold malay female after presentation with sore throat, fever and odynophagia, was diagnosed with mucoepidermoid carcinoma of the soft palate. Get detailed information about the treatment for newly diagnosed and recurrent salivary gland cancer in this summary for clinicians. A case of clear cell mucoepidermoid carcinoma mec of the hard palate with extensive intratumoural calcifications visible on computed tomography ct scans and histologic sections is.
Pdf mucoepidermoid carcinomas mecs of minor salivary gland origin are rare in children and adolescents and have been reported rarely. This antibody although less sensitive than the polyclonal antibody used in other reports lopes et al. Mucoepidermoid carcinoma genetic and rare diseases. Neville, 2002 mucoepidermoid carcinoma appears as asymptomatic swellings in minor salivary glands, being the second most common site of occurrence after the parotid gland, most commonly located on palate, followed by retromolar area. It has a slight female predilection and usually presents as a painless, rubberlike or soft mass, which may be fixed or mobile. Joseph dental college, duggirala, eluru, andhra pradesh, india. We hope that this case report will contribute to the enlightenment of the behavior and prognosis of pediatric. Mucoepidermoid carcinoma can also be found in other organs, such as bronchi, lacrimal sac, and thyroid gland mucicarmine staining is one stain used by pathologist for detection. The majority of cases occurring in the 4th and 5th decades of life and they are histologically lowgrade malignant neoplasm usually affecting the mandible. Discussion mucoepidermoid carcinoma of oral cavity arises in the ductal epithelium of major and minor salivary gland. Her mucoepidermoid carcinoma was located at the left upper abdomen, arising from the pancreatic body. Minor salivary gland mucoepidermoid carcinoma in children. It makes up about 30% of all malignant salivary gland tumors and about 10% to 15% of all salivary gland tumors. The overall 5year survival rates vary from 92 to 100% in lowgrade tumors, 62 to 92% in intermediategrade tumors, and 0 to 43% in highgrade tumors pires et al.
Here, a 63yearold woman with left upper abdominal pain and abdominal distension is presented. Literature regarding their clinical features and biologic behavior is scanty. Represents 2 nd or 3 rd most common minor salivary gland malignancy 1726% 1st mucoepidermoid carcinoma rare in reported asian series female preponderance 2 4. While the parotid and submandibular glands have been reported as predominant sites for oncocytic mec omec, the palate and minor salivary glands are rare sites for occurrence. A 33yearold male patient with mec of the hard palate was treated as an acute odontogenic infection, which. Occasional focal sebaceous cells, goblet type cells, oncocytic change, inflammatory reaction to extravasated mucin or keratin. Affected glands are most commonly located in the palate followed by lower lip. This pattern most likely reflects the relative distribution of minor salivary glands in this area of the upper aerodigestive tract. Most common salivary gland type tumor in the lung, tends to arise centrally similar morphology to mucoepidermoid carcinoma arising in the head and neck with a mixture of mucous cells, squamous cells and intermediate cells. Mucoepidermoid carcinoma with distant metastases to the. Mucoepidermoid carcinoma of maxillary sinus pathology.
I had surgery to remove a mucoepidermoid carcinoma from my palate on august 10, 2010. Histologically, mec is comprised of a mixture of cell types including mucous, epidermoid, and intermediate cells that can be. Highgrade mucoepidermoid carcinoma of maxillary sinus. Had a surgery 20 days ago to remove a lump on my right palate 1. Mucoepidermoid carcinoma definition of mucoepidermoid. It accounts for mucoepidermoid carcinoma of the palate utilizing 18 ffdg petct sankaran sudhakar, raga geethika velugubantla, swathi erva, and sai kiran chennoju department of oral medicine and radiology, st. This case report represents a retrospective clinical analysis of five minor salivary gland mucoepidermoid. A notable finding anuradha ananthaneni, haripriya ponnapalli, mohammad asif kiresur, sv krishna chaitanya department of oral and maxillofacial pathology, st. There are some reports of mec with unusual distant metastases 2. Lowgrade mucoepidermoid carcinoma of the hard palate. Mucoepidermoid carcinoma involving the palate with lamellated calcifications. Mucoepidermoid carcinoma mec is a malignant epithelial tumor that arises from the pluripotent cells of excretory ducts of salivary gland.
In children and adolescents, mucoepidermoid carcinomas have a female predilection and occur most commonly on the hard or soft palate or. However, despite the low overall incidence, there is a high incidence of malignancy in these young patients which is reported to be above 50 %, with mucoepidermoid carcinoma mec predominating. Pdf mucoepidermoid carcinoma of the palate in a child. Mucoepidermoid carcinoma with distant metastases to the kidney, adrenal gland, skull and gluteus maximus muscle. Mucoepidermoid carcinoma mec is a malignant epithelial neoplasm composed of varying proportions of mucous, epidermoid, intermediate, columnar, and clear cells and often demonstrates prominent cystic growth. Mucoepidermoid carcinoma of oral mucosa bmj case reports. Mucoepidermoid carcinoma mec accounts for approximately 30% of malignant salivary gland tumors and approximately 30% occur in minor salivary glands. Whereas, mucoepidermoid carcinoma of high grade malignancy strongly resembles squamous cell carcinoma. Mucoepidermoid carcinoma of maxillary sinus original research paper dr. It has a female predilection and is uncommon in the first decade of life. Mucoepidermoid carcinoma is a type of cancer of the salivary glands. Mucoepidermoid carcinoma of palatal minor salivary glands. Clinical and demographic data are summarized on supplementary file s2.
Ive been told margins were free and i dont need any radiation or chemio. Mucoepidermoid carcinoma soft palate malignant epithelial salivary gland neoplasm 10% of all salivary tumors, 30% of all salivary malignancies about 30% of these tumors arise from the minor salivary glands in the buccal mucosa and soft palate, the rest from major salivary glands arises from ductal epithelium, has both epidermoid and mucinous components. Original article morphological heterogeneity of oral salivary gland. A rare case of mucoepidermoid carcinoma of the nasal. These cases represented 19% of the total, and 4 1 yo of malignant, minor salivary gland neoplasms. Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults. Pdf salivary gland tumors are rare in children but when they involve the minor salivary glands, there is an increased risk that they will be. Histocytologic grading of mucoepidermoid carcinoma of major salivary glands in prognosis and survival.
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